The Effect of X-radiation on the Multiplication of Influenza a Virus in Embryonate Eggs

نویسندگان

  • Herman T. Blumenthal
  • Donald Greiff
  • Masahiro Chiga
  • Henry Pinkerton
چکیده

Groups of embryonate eggs were given 250, 500, 750, and 1000 r of x-radiation. 18 hours later, these 4 groups, together with a control group, were injected intra-allantoically with influenza A virus. Radiation at all dosage levels caused significant changes in the infectivity titre curves during the next 90 hours. The most striking alterations were the prolonged incubation period and the uniformly low infectivity titre in the group of eggs given 750 r.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of X-radiation on the Multiplication of Rickettsia Mooseri in Embryonate Eggs

The multiplication of Rickettsia mooseri in fertile eggs is speeded up and quantitatively increased by single dose x-radiation given either 24 hours before or 48 hours after inoculation. This effect is noted at all dosage levels studied, ranging from 100 to 1500 r. The rickettsiostatic effects of high incubation temperature (40 degrees C.) and of streptomycin are neutralized by radiation, but t...

متن کامل

Further Studies on the Effects of X-radiation on the Multiplication of Rickettsia Mooseri in Embryonate Eggs

The effect of x-rays on the growth of rickettsiae in the embryonate egg was investigated. The intensifying effect of x-radiation of the host on rickettsial growth can be attributed to alterations of the cells of the host that persist at least 7 days. The greatest enhancement of the growth of rickettsiae occurred when moderately infected cells were irradiated. These experiments indicate that x-r...

متن کامل

Effect of low dose gamma-radiation upon Newcastle disease virus antibody level in chicken

Background: The specific antibody response against Newcastle disease virus (NDV) in the blood serum of chickens hatched from eggs exposed to low dose gamma-radiation was studied. Materials and methods: Two groups of eggs of commercial meat chicken lines were irradiated with the dose of 0.30 Gy 60Co gamma-rays before incubation and on the 19th day of incubation, respectively. The same num...

متن کامل

The Level of Lactic Dehydrogenase Activity as an Indicator of the Growth of Influenza Virus in the Embryonate Egg

The relation, between time and the levels of lactic dehydrogenase activity of chorioallantoic fluids from embryonate eggs infected with the PR8 strain of influenza virus were determined quantitatively. The mean values, based on 10 determinations for each time interval, followed a sigmoid curve, with the greatest rates of change occurring between 48 and 72 hours after the inoculation of virus. T...

متن کامل

Monitoring virus harvesting time in embryonated chicken eggs inoculated with avian influenza H9N2 vaccine strain

Knowledge of virus and replication kinetic is one of the most important issues in the vaccine production. The present study aimed to evaluate the best harvesting time of H9N2 avian influenza virus (AIV) vaccine strain inoculated in specific pathogen free (SPF) embryonated chicken eggs (ECE)s. For this purpose, 10-5 dilution of AIV (A/Chicken/Iran/99/H9N2) was inoculated into 336, 11-day old ECE...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 97  شماره 

صفحات  -

تاریخ انتشار 1953